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Prognostic factors for visual acuity in patients with LHON after gene therapy

This retrospective study investigates prognostic factors affecting the visual acuity after a single intravitreal injection of rAAV2-ND4 gene therapy in 53 patients with Leber’s hereditary optic neuropathy (LHON) with mutation at site 11 778. Patients were reviewed one and three...

Case report of Leber hereditary optic neuropathy (LHON)

This case report presents a 74-year-old male patient who developed LHON, with a previous diagnosis of bilateral macular holes. LHON occurs predominantly in healthy young men and onset in older age ranges increases the likelihood that the patient will have...

A paediatric case of central retinal artery occlusion following antibiotics and decompression surgery for orbital cellulitis

Orbital cellulitis is an ophthalmic emergency that warrants urgent management in the hospital setting [1]. This occurs more frequently in the paediatric population where it is often secondary to sinus infections. Delay in treatment could result in severe complications including...

Occult spread of squamous cell carcinoma into the orbit

The authors describe two cases that may represent perineural spread of cutaneous squamous cell carcinoma (SCC) into the orbit. Both cases had cutaneous squamous cell carcinomas in the region of the lateral orbital wall (innervated by the zygomatico-temporal nerve) which...

Triamcinolone (TA) deposits following subcutaneous injection to treat chalazion

Chalazia are chronic lipogranulomatous inflammations of the eyelid secondary to a blocked meibomian gland. Whilst most resolve spontaneously, certain chalazia warrant treatment. Options include incision and curettage (I&C), lesion excision, intralesional steroid injections, and botox injections [1]. I&C is usually...

The focus group

I love conferences. Euretina I love above all others, and when it came to London in 2014 I was determined to attend. A few weeks before the conference was scheduled to begin a well-known pharmaceutical company sent me an email...

The ROP Network: a south-south collaboration to improve care for premature babies

Retinopathy of prematurity (ROP) is a disorder of the immature preterm retina and a leading cause of preventable, irreversible blindness in children. There are 15 million preterm births annually, and over 32,000 neonates became blind from ROP in 2010 [1]....

Preview: Oxford Ophthalmological Congress

Between 1–3 July, we will be heading down to England for the 107th Oxford Ophthalmological Congress.

Strange Sequelae Succeeding ‘Surfer’s Eye’

Ophthalmologists in the UK are relatively infrequently faced with a patient requesting surgery for a pterygium. This condition is more common where ultraviolet exposure is greater, especially if coupled with activities associated with ocular surface irritation. For this reason, a...

Static subjective visual vertical (SVV) in the normal visual system

Graviception is the perception of a persons’ orientation relative to gravitational force. This can be measured by means of subjective verticals, which can be divided into three tests: subjective visual vertical (SVV), subjective postural vertical (SPV) and subjective haptic vertical...

γδ T cell depletion does not affect fungal keratitis

Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...

Orbis marks 100-millionth antibiotic dose in the fight against trachoma in Ethiopia

Orbis and partners mark historic 100-millionth dose of azithromycin antibiotics in the fight to eliminate blinding trachoma in Ethiopia by 2030. This milestone was achieved 20 years after Orbis began leading mass drug administrations.