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MicroRNA inhibits corneal neovascularisation
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
PD-1 and PD-L1 in exenteration specimens
This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...
Effect of intravenous mannitol in post vitrectomised eyes
The purpose of the study was to evaluate the effect of intravenous mannitol 20% on intraocular pressure in vitrectomised silicone-oil filled eyes. A prospective analysis of consecutive patients was undertaken with their fellow eyes taken as controls. Thirty-one patients were...
Uveitic glaucoma
The purpose of this retrospective study from two tertiary Institutions in Israel over a period of 13 years, is to present the long-term outcomes of uveitic glaucoma and to identify risk factors for progression. The study included 34 patients (53...
N-T asymmetry in tracking eye movements
The current study aimed to quantify and compare the visual tracking responses of two sensory induced strabismic juvenile monkeys during monocular smooth pursuit, ocular following response and optokinetic nystagmus (OKN). Monkey 1 had esotropia and monkey 2 had exotropia. Both...
Topical insulin for neurotrophic ulcers
This retrospective case series described the use of topical insulin drops as an aid in treatment of refractory neurotrophic corneal ulceration in six patients. Insulin drops were prepared under sterile conditions from standard insulin preparations mixed with artificial tears containing...
DIY IOP – does it work?
Measuring intraocular pressure (IOP) plays a major role in glaucoma care as IOP is a parameter, along with visual field progression and optic disc cupping used to assess treatment effect. While Goldmann tonometry (GAT) is the gold standard, it only...
Keratoconus cone variants
This retrospective study examined correlation between three keratoconic parameters to further understand anatomy of keratoconic cones. Kmax and pachymetry of the thinnest point were obtained from the Pentacam scans. Decentration was calculated as distance from the corneal vertex to the...
Intermittent exotropia with a positive Bielchowsky head-tilt test
This is a retrospective study from Korea, of 118 patients’ charts with intermittent exotropia (IXT) and divided into two groups; 50 patients showed positive Bielchowsky head tilt test (BHTT) and 68 with negative BHTT. Significant differences (p<0.05) in the parameters...
Strabismus and scleral buckling
The authors examine the incidence of strabismus following scleral buckle for retinal detachment surgery and the factors that influence the strabismus, its incidence, preventative measures and treatment options. This was a retrospective review of 344 patients (360 eyes) with a...
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
