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Clinical & Experimental Ophthalmology journal cover image

Atropine treatment for myopia in western countries – rationale

5 October 2020 | | Cataract and Refractive
This preliminary study sets out the rationale, methodology and participant baseline characteristics for the Western Australia Atropine for the Treatment of Myopia (WA-ATOM). It is a double masked randomised placebo-controlled trial. This study is designed to be combined with the...

Retinal prosthetics: science fiction or a vision for the future?

2 December 2019 | | Retina / Uvea / Vitreous, Ophthalmology
“Is it a fact – or have I dreamt it – that, by means of electricity, the world of matter has become a great nerve, vibrating thousands of miles in a breathless point of time?” – Nathaniel Hawthorne, The House...

Genetic profiles of primary strabismus

1 December 2018 | | Paediatric Ophthalmology / Strabismus | esotropia, exotropia, genetics, pedigree analysis, primary concomitant strabismus
The authors explore the pedigree analysis of familial cases of primary concomitant strabismus (PCS) to unravel the genetic determinants of this strabismus. Of 2301 cases of PCS, 39 (1.7%) had familial clustering. This study recruited 18 families with esotropia and...

Medical and eye health teams defy odds to deliver treatments for trachoma in Ethiopia, but millions worldwide risk return of disease amid UK aid cuts

27 January 2022
Ophthalmologists, nurses, and eye health workers in Ethiopia defied the odds to treat millions with trachoma-fighting antibiotics and surgeries - despite cuts to UK Aid assistance threatening eye care. This World Neglected Tropical Diseases Day Orbis, the international eye care...
Ophthalmologica journal cover image.

Intravitreal dexamethasone in diabetic macular oedema (DMO) - enhancing the response to anti-VEGF in non- or poor responders

3 February 2023 | | Retina / Uvea / Vitreous | Aflibercept, Anti-VEGF, Dexamethasone implant, Diabetic macular oedema, Persistent, Ranibizumab, Resistant
This study aimed to describe the outcomes of a switch back from DEXi (dexamethasone implant) to anti-VEGF therapy in eyes that were treated temporarily with DEXi after an initial poor response to anti VEGF. Twenty-three eyes of 17 patients were...
Ophthalmologica journal cover image.

Association between neurodegeneration and macular perfusion in the progression of diabetic retinopathy

9 August 2023 | | Retina / Uvea / Vitreous | Diabetes, Neurodegeneration, Progression, Retinopathy, Vessel closure
In this prospective three-year longitudinal study, the authors aimed to explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with non-proliferative diabetic retinopathy (NPDR). The participants included 74 individuals with type 2 diabetes, NPDR, and Early...
Ophthalmologica journal cover image

Optic disc pit maculopathy: an optical coherence tomography study

4 October 2023 | | Retina / Uvea / Vitreous | Maculopathy, Natural course, Optic coherence tomography, Optic disc pit, Retinal fluid
This was a single-centre, retrospective observational case series that aimed to analyse the change of optical coherence tomography (OCT) characteristics in the natural course of optic disc pit maculopathy (ODP-M) and their effects on visual acuity. Twenty-two eyes of 22...

Acute retinal necrosis presumably caused by Epstein-Barr virus infection

1 October 2015 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Acute retinal necrosis (ARN) is an uncommon, but serious and potentially blinding condition. ARN is characterised by panuveitis, occlusive vasculopathy and progressive peripheral necrotising retinitis. The diagnosis is clinical but confirmation is sought via aqueous and vitreous sampling. Varicella zoster...

An anterior segment lump: a diagnostic and treatment challenge

2 February 2024 | | Ocular Pathology and Oncology
Case presentation A 50-year-old female presented to eye casualty with a lump on the left medial lower eyelid with associated redness and occasional bleeding. The lump was present for a few months with recent enlargement (Figure 1). Her past medical...

Shifting the paradigm of managing patients in medical retina: how real-world data can help us to improve clinical practice

1 February 2015 | | Retina / Uvea / Vitreous
The ophthalmic subspecialty of ‘medical retina’ has undergone dramatic changes in recent years. With the introduction of ranibizumab (Lucentis, Novartis), a specialty formerly dominated by laser-based therapies has been transformed to become, in large part, pharmacotherapy-based. To date, these pharmacotherapies...

Eye Capacity: clinical need should drive ophthalmic service provision

1 February 2014 |
Almost two million people in the UK suffer sight loss, a number forecast to double over coming decades. Major causes of blindness are age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, cataract and uncorrected refractive error. Prevalence of these sight-threatening conditions...

Usher syndrome: an overview

22 September 2020 | | Ophthalmology, Retina / Uvea / Vitreous, ONLINE EXCLUSIVE ARTICLES
Usher syndrome is the most common hereditary condition that affects both vision and hearing. It is an autosomal recessive condition characterised by retinitis pigmentosa (RP) and bilateral sensorineural hearing loss [1,2]. Usher syndrome is the cause of approximately 10% of...