You searched for "proptosis"
Thyroid eye disease
Thyroid eye disease (TED) is an autoimmune condition with a spectrum of signs and symptoms, usually associated with Graves’ hyperthyroidism. The diagnosis is based on history and physical examination but there are further investigations that can aid diagnosis if unclear....Prognostic factors for visual acuity in patients with LHON after gene therapy
5 February 2020
| Ivan Yip
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Retina / Uvea / Vitreous
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Leber's hereditary optic neuropathy, ND4, gene therapy, prognosis
This retrospective study investigates prognostic factors affecting the visual acuity after a single intravitreal injection of rAAV2-ND4 gene therapy in 53 patients with Leber’s hereditary optic neuropathy (LHON) with mutation at site 11 778. Patients were reviewed one and three...
Visual acuity conversion to digital acuity
5 April 2022
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
The author proposes a basic set of evidence-based digital acuities for alpha vision to facilitate formatting of visual acuity data uniformly. This work was informed by a review of the literature. A full table provides US and international classification of...
Knobby eye syndrome
1 April 2019
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
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Magnetic resonance imaging, myopia, staphyloma, strabismus
This study used high resolution MRI to demonstrate and evaluate globe shape in axial high myopia and identify and characterise those with prominent equatorial staphylomata that deflect extraocular muscle paths and presumably alter motility patterns in strabismus. The study included...
Confocal microscopy and corneal graft rejection
1 February 2016
| Magdalena Popiela
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Cornea / External Eye Disease
Forty-five patients following penetrating keratoplasty (PK) were examined with the HRT III Rostock Cornea Module confocal microscope at various points after their surgery for two years. Activated keratocytes (AKs) were counted manually and their mean number evaluated. A pattern was...
Strabismus in thyroid eye disease
1 April 2017
| Richard Harrad
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Paediatric Ophthalmology / Strabismus
Pathogenesis Thyroid eye disease (TED) is an auto-immune condition, in the initial phase there is lymphocytic infiltration and oedema of the extraocular muscles with deposition of glycosaminoglycans and hyaluronic acid and adipogenesis, which can lead to an increase in the...
VISION 2020 LINKS: Retinoblastoma in Africa
1 October 2015
| Marcia Zondervan, Lindsay Hampejsková, Sunday Abuh, Sharai Shamu, Mayuri Makan, Rosie Brennan, M Ashwin Reddy, Richard Bowman
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AMD, Emergency Ophthalmology, Genetics, Ophthalmology, Optometry, EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
The VISION 2020 LINKS Programme is part of the ‘VISION 2020: The Right to Sight’ global initiative to eliminate avoidable blindness [1]. The LINKS Programme works with overseas eye departments to help identify priorities and match their priority needs with...
AOP launches research into key reforms proposed for primary eye care services in Wales
The Welsh Government put forward proposals for major reforms of primary eye care servicesPD-1 and retinal ganglion cell death
1 February 2016
| Graham Wallace
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Apoptosis, Large retinal ganglion cells, Neuroprotection, Optic nerve crush, Programmed cell death-1
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
MicroRNA mediate retinoblastoma signal transduction
1 October 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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KEGG, cell migration, colony formation, microRNA-21, phosphorylation signaling pathway, retinoblastoma, seed-targeting, tiny anti-miRNA
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Erythropoietin in healing corneal epithelial defects in rabbits
1 December 2013
| Bheemanagouda Patil
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Cornea / External Eye Disease
Corneal epithelial defects heal slowly in patients with diabetes, limbal stem cell deficiency and severe chemical burns. Erythropoietin is a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors as well as nonhematopoietic cells. In...
The challenge of chorioretinal folds in virtual eye clinics
3 June 2024
| Noorulain Khalid, Faizan Hashmi, Adam Riaz, Hadi Ziaei, Abha Gupta
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Retina / Uvea / Vitreous, Orbit
Chorioretinal or choroidal folds are parallel striations involving the retina, retinal pigment epithelium (RPE), Bruch’s membrane, and inner choroid [1]. They can arise from compressive stress on these layers, and their presence often serves as a diagnostic marker for underlying...