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Natural history of idiopathic intracranial hypertension depending on incidental or symptomatic presentation

The authors present a large retrospective review cohort of consecutive patients diagnosed or presumed idiopathic intracranial hypertension (IIH) over a three-year period at a single tertiary centre. Patients on medication with a known aetiology for IIH were excluded. The cohort...

Phakic iris clip lenses and endothelial cell loss

This retrospective observational study included long-term results on endothelial cell losses in highly myopic eyes, which underwent phakic iris-clip lens implantations. Included in the analysis were 113 eyes with mean preoperative spherical equivalent (SEQ) of -14.67 +/- 5.15 Diopters (D)....

MicroRNA inhibits corneal neovascularisation

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

Diagnosis of amiodarone-associated optic neuropathy

Amiodarone is a widely used anti-arrhythmic drug. Several case reports describe optic neuropathy which has been linked to its use. This case series discusses the diagnosis of amiodarone-associated optic neuropathy (AAON) and its potential impact on cardiac therapy. The authors...

Dynamics of interocular suppression

The main aim of this study was to determine the development of the depth of interocular suppression in the course of occlusion treatment in amblyopia as well as its correlation with changes in visual acuity. The authors investigated whether presence...

A possible biomarker for diabetic retinopathy

Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...

Bilateral internuclear ophthalmoplegia

Bilateral internuclear ophthalmoplegia (INO) has been linked with various pathological conditions of the central nervous system such as multiple sclerosis, stroke, tumours and brainstem inflammatory processes. This unusual case report describes a case of a 45-year-old female patient presenting with...

Nanofiber-based hydrogels prevent capsular opacification

Lens refilling is the replacement of the lens with a silicone polymer in an otherwise intact lens capsule. However, capsular opacification (CO), resulting in reduced visual acuity, is a major complication of these injectable accommodating lenses. Opacification is due to...

Resveratrol protects against steroid induced intraocular pressure

Topical and systemic steroid delivery is a very effective treatment for many ocular conditions but is compromised by raised intraocular pressure which in turn leads to death of retinal ganglion cells and irreversible blindness. This is an important consideration with...

Genetic analysis of choroideremia families

Choroideremia (CHM) is a rare X linked recessive chorioretinal dystrophy. Symptoms include nyctalopia and progressive peripheral field loss. Female carriers may have mild symptoms. Choroideremia is known to be caused by a mutation in the CHM gene. A multicentre human...

Same day air bubble removal after DSEK/DSAEK

A complete air removal on same day as descemet’s stripping endothelial keratoplasty (DSEK/DSAEK) leads to prompt restoration of the anterior chamber and thus has been hypothesised to assist with the recovery of endothelial function and promote graft adhesion. The results...

RPE use similar pathway to regulatory T cells to inhibit immune response

Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....