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Possible mechanism for infant development of secondary glaucoma
The authors consider published evidence with regard to potential causative mechanisms for secondary glaucoma that follows infant lensectomy. They review clinical and laboratory studies. The mechanism they propose is that the original lensectomy surgery releases immature anterior lens cells into...
Outcomes with small aperture IOLs
This study aimed to compare the clinical outcomes following the implantation of an extended depth of focus small-aperture intraocular lens (IOL) (IC-8; AcuFocus, Irvine, CA) for presbyopia correction when implanted monocularly or binocularly. Visual outcomes, defocus curve, patient satisfaction, and...
Effect of heredity on risk of diabetic retinopathy
This study used survival analysis on 2199 patients who had reached vision-threatening diabetic retinopathy to investigate the contribution of heredity to diabetes together with other known risk factors for the development of either proliferative diabetic retinopathy (PDR) or diabetic macular...
Subperiosteal abscess management in adolescents and adults
This is a retrospective study looking at the clinical and treatment profiles of patients with orbital subperiosteal abscess (SPA) in an adolescent and adult population. SPA is rarer in this age group compared to a paediatric population (less than nine-years-old)...
Macular pigment and dark adaptation in older population with normal maculas
Macular pigment (MP) such as lutein, zeaxanthin and meso-zeaxanthin are highly concentrated in the fovea. They protect the retina from damage of ambient blue light via antioxidant properties. In older eyes with normal healthy retina, macular pigment optical density (MPOD)...
Is laser refractive surgery safe for patients taking isotretinoin?
This multicentre, retrospective, interventional case series assesses the outcomes of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in 113 patients taking isotretinoin between January 2003 and September 2017. Isotretinoin is contraindicated for LASIK and PRK and patients are...
Aberrant regeneration rates following traumatic oculomotor palsy
Traumatic oculomotor nerve palsies can result in aberrant regeneration / synkinesis which impairs normal facial function. In this paper, the authors retrospectively reviewed the records of 16 patients with traumatic oculomotor nerve palsies who were treated with or without steroids....
Use of the RAPDx device to evaluate efficacy of treatment in patients with optic nerve disease
The RAPDx objectively determines the RAPD magnitude by alternately presenting light stimuli to each eye and deriving amplitude and latency scores. The authors of this paper evaluated the amplitude and latency scores from the RAPDx together with other ophthalmic investigations...
Narrative review of idiopathic intracranial hypertension in children / adolescents
Idiopathic intracranial hypertension (IIH) affects both children and adults. Whilst the majority of IIH is mainly seen amongst adults, it also affects children. There are currently no clinical trials in IIH for those who are adolescents or children. The aims...
Brolucizumab in age-related macular degeneration, HAWK Study
The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...
Bromfenac versus betamethasone in diabetic macular oedema
This is a randomised, prospective, single-centre trial in patients diagnosed with diabetic macular oedema (DMO) with central subfield thickness (CST) of 250-500µm, who refused anti-VEGF treatment. Nineteen eyes of 19 patients were randomised to bromfenac (BF) or betamethasone (BM) drops,...
