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Cataract progression after Nd-YAG laser iridotomy in primary angle-closure suspect eyes
A total of 889 of eligible bilateral primary angle-closure suspect (PACS) patients were recruited from the Zhongshan Angle Closure Prevention Trial. One randomly selected eye received laser peripheral iridotomy (LPI), while the fellow remained untreated. Cataract was graded by the...
Anterior segment OCT predicts gonioscopic angle closure
This is a prospective observational study of 342 subjects over four years. Sixty-five were controls who had open angles both on gonioscopy and AS-OCT, while 277 had open angles only on gonioscopy but iridotrabecular contact (ITC) on AS-OCT (one to...
Normal videonystagmography data
The authors report on the smooth pursuit and saccadic eye movement waveforms elicited from normal patients while viewing standardised calibrated targets. Serial trials were performed on each patient to determine test / retest reliability: nine trials producing 117 results by...
A case series of acute visual loss following excessive alcohol and / or drug use
This study presents three cases of so called Saturday night retinopathy, an acute visual loss following intravenous drug abuse and stupor, leading to continuous pressure on the orbit while asleep. All three cases presented with acute vision loss and had...
Changes in C:D ratio of premature infants with enlarged C:D ratios
This retrospective observational study examined the longitudinal alterations in cup to disc ratio (CDR) among premature infants exhibiting enlarged CDR and normal intraocular pressure (IOP) up to two years. Among the 283 infants, 13.4% manifested an enlarged CDR. In this...
Progression of macular atrophy in Stargardt disease
The authors present a study of a cohort of patients with genetically proven ABCA4 gene mutation related Stargardt disease. They aimed to quantify the effect of lesion location and topography on disease progression using fundus autofluorescence imaging. One hundred and...
Medical management and diabetic retinopathy progression
The ACCORD Eye Study was designed to evaluate the benefit of intensive glycaemic control (HbA1c <6.0% vs 7.0-7.9%), intensive systolic blood pressure control (<120mmHg vs. <140mmHg), and combined fenofibrate and simvastatin therapy in the development and progression of diabetic retinopathy....
The prevalence of macular cysts in patients with clinical cone-rod dystrophy determined by spectral domain optical coherence tomography
Cone-rod dystrophy is a progressive photoreceptor disorder which has multiple inheritance patterns. It is rare, with a prevalence of 1 in 40,000. Macular cysts are well recognised in other photoreceptor conditions such as retinitis pigments and choroideraemia, while they are...
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
Enzymatic clearance of anterior chamber infiltrate in uveitis
Aqueous humour (AH) which fills the anterior chamber (AC) of the eye provides nutrients to the cornea and the lens. Clearance of cellular and particular matter from AH is necessary for good visual acuity. In part this is achieved by...
Microperimetry of subretinal drusenoid deposits
Subretinal drusenoid deposits (SDD), originally termed ‘reticular pseudo-drusen’, have recently been identified by histology and optical coherence tomography (OCT) as aggregations located in the subretinal rather than the sub retinal pigment epithelium (RPE) space. These deposits affect the amount of...
