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Intravitreal Ziv-Aflibercept: safety analysis

Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...

Systemic screening in adnexal lymphoma

This is a retrospective review of 119 patients diagnosed with ocular adnexal lymphoma, 85 of whom had primary adnexal disease and 34 had previously been diagnosed with lymphoma outside the ocular adnexa. Sixty-eight of the primary and 24 of the...

Intensive diabetes therapy and ocular surgery in type 1 diabetes

The Diabetes Control and Complications Trial (DCCT) ran between 1983 and 1993 and showed that intensive glycaemic control was beneficial in reducing diabetic retinopathy in type 1 patients. There was a 76% reduction in onset of retinopathy and a 52%...

Persistence of Ebola virus in ocular fluid during convalescence

The most recent Ebola outbreak has infected over 26,300 patients, but also resulted in the highest number of survivors in history. Uveitis has been described during the convalescent period, but Varkey and colleagues report, for the first time, finding viable...

How common is ocular trauma in children and what are the clinical features?

The authors present a multicenter retrospective case review with the aim of reporting the incidence and characteristics of paediatric ocular trauma. Records for individuals aged 18 and under with a diagnosis of globe, orbit or adnexal injury over a 10-year...

The ocular manifestations of COVID-19: an overview of current literature

Although respiratory symptoms are the most frequent manifestation of COVID-19, multi-organ involvement has been demonstrated, including ocular manifestations. The author investigates how the eye can be affected. The SARS-CoV-2 virus responsible for the COVID-19 pandemic has presented a significant public...

Biomaterials and Regenerative Medicines in Ophthalmology (Second Edition)

With advancement in science and technology in the last decade, the role of biomaterials and regenerative medicines has become increasingly important in the management of various ocular disorders. This book highlights the role of biomaterials in the restoration of vision...

Myasthenia Gravis Masquerading as a Third Cranial Nerve Palsy

A 65-year-old man presented with a week’s history of binocular diplopia (in all directions of gaze) and a right partial ptosis. He was systemically well. His past medical history was unremarkable except for vitiligo. At presentation acuity was 6/6 bilaterally....

Friendly felines and a spot diagnosis

A nine-year-old girl presented to me in eye casualty with a three-week history of blurred vision in her left eye. Otherwise she was apparently well, with no past ophthalmic, medical, drug or relevant family history. Visual acuity was 6/4 right...

Proning and the pandemic - ocular complications seen in critical care

Priyanka Sanghi and her co-authors explore the ocular complications seen in critical care units throughout the country as we treat patients through this challenging time. The SARS-Cov-2 (COVID-19) pandemic has placed the NHS and critical care services under immense strain,...

The history of ophthalmology: John Argyll Robertson and Douglas Moray Cooper Lamb Argyll Robertson

The author shares the story of an extraordinary father and son, two of the major figures in defining the specialty of ophthalmology as we know it today. The renowned Glasgow Surgeon Peter Lowe described ophthalmic surgery in his legendary surgical...

Superior oblique sagittalisation

This paper reports two cases with anomalous posterior course of the superior oblique tendon with insertion nasal to the superior rectus tendon. Both presented with Brown syndrome-like clinical scenarios. The cases were a five-year-old female and four-year-old male. Diagnosis was...