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Sickle cell eye disease: an overview of vitreoretinal complications and their surgical management
Sickle cell disease is the most common genetic disorder worldwide and is associated with lifelong anaemia, intermittent pain and multi-organ morbidity. Ocular involvement can be associated with significant visual impairment due to the complications of proliferative sickle retinopathy (PSR). Occasionally...
Associations of esotropia with shunts
This study explored the characteristics and outcomes of children with esotropia and ventriculo-peritoneal (VP) shunt placement due to hydrocephalus. The authors conducted a retrospective study of 16 patients (nine female, seven male) aged three months to 5.6 years (mean 17...
Injection of methotrexate into silicone oil-filled eyes for grade C PVR
Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...
Corneal crosslinking in pellucid marginal degeneration
Fourteen studies were included in this first review examining the use of corneal-crosslinking (CXL) to treat pellucid marginal degeneration (PMD). PMD is a bilateral, non-inflammatory corneal thinning disorder characterised by inferior peripheral corneal thinning 1-3mm from the limbus in the...
Long-term effect of YAG LPI on corneal endothelium in PACS
This is a single-centre randomised controlled trial of 875 patients with bilateral primary angle closure suspect (PACS) who received YAG laser iridotomy (LPI) prophylactic treatment in one eye randomly and the fellow eye served as control over 72 months. Central...
Lamellar patch grafts utilising cornea remnants from DMEK/PKP
The authors retrospectively reviewed 23 lamellar patch grafts performed over a six-year period for tectonic indications in corneal thinning and perforations. The anterior stroma of corneal endothelium peeled for descemet membrane endothelial keratoplasty (DMEK) were used to prepare circular lamellar...
Treatment and outcomes for Peters anomaly (PA)
The purpose of this study was to evaluate the experience of patients with Peters anomaly (PA) and their treatment results. The study reviewed records of 27 patients (32 eyes); 74% male. Treatment included medical follow-up, optical iridectomy and penetrating keratoplasty...
Corneal dellen following strabismus surgery
This study aimed to evaluate the frequency of corneal dellen (CD) development, the healing process and associated factors that affect the development and healing of CD formation after strabismus surgery. This study retrospectively reviewed 1264 eyes of 714 patients from...Hospital wins funding to investigate sickle cell sight loss.
The hospital trust is the first in the UK to lead on a research project to understand the impact of sickle cell disease on eyesight.
Effect of rebubbling after DMEK
This study objectively evaluated the impact of rebubbling on postoperative corneal clarity and endothelial cell loss (ELD) after DMEK. This was a retrospective analysis of 132 consecutive DMEK cases performed for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy. Patients were...
HLA-B27 anterior uveitis
HLA-B27 has previously been shown to have an association with uveitis, ankylosing spondylitis, reactive arthritis, ulcerative colitis and psoriasis. The authors of this review provide an update of the epidemiology of HLA-B27 associated ocular disorders. There is great variation amongst...
