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1746 results found

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

1 August 2018 | | Retina / Uvea / Vitreous | Everolimus, mammalian target of rapamycin (mTOR), proliferative vitreoretinopathy, retinal detachment, ribosomal protein S6 (RPS6)
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Differential inhibition of EAU by CTLA4 and IL-6

1 February 2016 | | Retina / Uvea / Vitreous | Biologic, CTLA4, Cytokine, Experimental autoimmune uveitis, T cell, Uveitis
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...

Erythropoietin in healing corneal epithelial defects in rabbits

1 December 2013 | | Cornea / External Eye Disease
Corneal epithelial defects heal slowly in patients with diabetes, limbal stem cell deficiency and severe chemical burns. Erythropoietin is a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors as well as nonhematopoietic cells. In...

Haag-Streit launches Eyesi Indirect Ophthalmoscope ROP simulator for retinal examinations on preterm infants

5 April 2024 | Research & Development
The Eyesi Indirect ROP is a mixed-reality simulator that offers a highly immersive training environment for proper device handling, with an embedded, didactically structured simulator curriculum to teach the diagnostic skills required for correct ROP classification.

Paediatric ptosis

1 December 2018 | | Ophthalmology, Paediatric Ophthalmology / Strabismus
Manoj Parulekar and colleagues provide a comprehensive overview of the diagnosis, assessment and management of childhood ptosis. Blepharoptosis (commonly referred to as ptosis – Greek, πτῶσις, ‘to fall’) is a condition where the upper eyelid is in an abnormally low...

Safe cataract extraction with underlying hypotonous cilio-choroidal detachment following trabeculectomy surgery

1 October 2018 | | Cataract and Refractive
The authors of this study (including the reviewer of this article) describe a surgical technique for phacoemulsification in the presence of shallow choroidal detachment owing to hypotony following trabeculectomy. In their case series, four eyes of four patients with advanced...

The treachery of images – making sense of OCT imaging

1 June 2016 | | Retina / Uvea / Vitreous, Imaging
In 1929 Belgian surrealist Rene Magritte produced his painting La Trahison des Images. It depicted an old fashioned pipe for smoking tobacco and underneath were the words “ceci n’est pas une pipe”, this is not a pipe. You may wonder...

End of an era: completing training. Tips for survival, fellowship applications and how to CCT

1 February 2019 | | Ophthalmology
Tafadzwa Young-Zvandasara shares the things he wishes he had paid more attention to when approaching the end of training. It is the end of an era, you are now ready to move on. Training has been filled with a structured...

A Multidisciplinary Approach to Neovascular Glaucoma in a Patient with Waldenström’s macroglobulinemia

1 December 2013 |
An 84-year-old Caucasian male attended eye casualty with a four month history of reduced vision, a dull ache and photophobia in both eyes. He had also reported dizziness, weakness and intermittent epistaxis in the nine months prior to presentation. There...

The paediatric cataract: an overview of the embryology and pathophysiology

5 February 2020 | | Ophthalmology, Paediatric Ophthalmology / Strabismus, Cataract and Refractive
In the first of the two articles (see Part 2 here) on paediatric cataracts, Samuel Aryee reviews the aetiology of this condition. Cataracts arise from opacification of the natural transparent lens, which can cause partial or total blindness. Although the...

Eye testing at home – developing an app for measuring vision

5 October 2020 | | Ophthalmology, Optometry, COVID-19
COVID-19 has made home vision monitoring a necessity. Stephanie Campbell shares how her idea for a vision testing app that would engage patients became a reality. Months before COVID-19 first began to mutate to its human host, there was a...

Viral conjunctivitis and COVID-19

23 March 2020 | COVID-19
A joint statement was released by the Royal College of Ophthalmologists and College of Optometrists on 19 March.