You searched for "Gene therapy"
Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
4 August 2021
| Jane Ashworth, Tsveta Ivanova, Susmito Biswas, Assad Jalil, Georgina Hall, Rebecca Redmond, Graeme CM Black (Prof), William Newman, Neil Parry, Jane CB Gray, Charlotte Skitterall
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EYE - Paediatrics, EYE - Vitreo-Retinal, EYE - General
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...
Prognostic factors for visual acuity in patients with LHON after gene therapy
5 February 2020
| Ivan Yip
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Retina / Uvea / Vitreous
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Leber's hereditary optic neuropathy, ND4, gene therapy, prognosis
This retrospective study investigates prognostic factors affecting the visual acuity after a single intravitreal injection of rAAV2-ND4 gene therapy in 53 patients with Leber’s hereditary optic neuropathy (LHON) with mutation at site 11 778. Patients were reviewed one and three...
Long-term effect of gene therapy on Leber’s congenital amaurosis
1 October 2015
| Jonathan CP Roos
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Retina / Uvea / Vitreous
After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...
Gene therapy: perspectives from young adults with Leber’s congenital amaurosis
5 June 2023
| Ivan Yip
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Retina / Uvea / Vitreous
The authors present their telephone survey data of 10 patients with a mean age of 24.4 years regarding their opinion on gene therapy for their Leber’s congenital amaurosis. Patients were recruited at the Hospital for Sick Children, Toronto. Of the...
Age and gender impacts effectiveness of new gene therapy treatments for eye diseases, new study finds
14 February 2025
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research, genetics, gene therapy, pathology, education, Adeno-Associated Virus, inflammation
Older women could be vulnerable to harmful inflammation from new gene therapies to treat incurable eye diseases, new research has found. The University of Bristol-led study, published in Molecular Therapy, reveal how age and gender affects inflammation caused by gene...
What's trending Aug/Sep 2021
4 August 2021
| David Ellis
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EYE - Cataract, EYE - Refractive, EYE - Cornea, EYE - Vitreo-Retinal, EYE - General
A round-up of the eye-related hot topics that have been trending on social media over the last few weeks. #algae #optogenetics Scientists in Paris have used optogenetics to partially restore sight in a blind man’s eye who was diagnosed with...
Developments in Ophthalmology: Ophthalmic Radiation Therapy Techniques and Applications
1 February 2015
| Sofia Rokerya
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EYE - Paediatrics, EYE - Strabismus, EYE - General, EYE - Neuro-ophthalmology
Radiation was discovered by Wilhelm Roentgen in 1895, and since then has been used to treat a variety of cancers. Its therapeutic properties have been widely used for ocular and periocular tumours and inflammatory disease, but the present era is...
What's trending Dec/Jan 2020
2 December 2019
| Stephanie Chiu
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EYE - Cataract, EYE - Refractive, EYE - Vitreo-Retinal, EYE - Glaucoma
#eyedoctor #banned #visamix-up #HomeOffice #hostileenvironment An ophthalmologist was left stranded overseas when the Home Office refused him entry due to a visa mix-up. Dr Chan was working as a fellow at Moorfields Eye Hospital until August 2019, then was offered...
What's trending Feb/Mar 2021
A round-up of the eye-related hot topics that have been trending on social media over the last few weeks. Happy New Year! Goodbye 2020, a year no one could have imagined, with our lives and headlines dominated by COVID-19 as...
ICG TTT for retinoblastoma
1 August 2016
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
Transpupillary thermotherapy (TTT) is a specific form of ocular TT using infrared radiation (diode laser). Indocyanine green (ICG) is also used to achieve the optimal phototherapy effect in eyes with minimal pigment. Twenty-one patients with 42 retinoblastomas in 30 eyes...
Primary intravenous chemotherapy (IVC) for Group D retinoblastoma
A retrospective review is reported of 64 group D retinoblastoma (RB) eyes (52 patients) treated with primary IVC, between 2002 and 2014 from two centres, in the UK and US. The median age at presentation was 11 months, 35 (67%)...Retinoblastoma management update (part 2): treatment, screening and surveillance, long-term follow-up and new developments
1 February 2017
| Manoj V Parulekar
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EYE - Oncology
Retinoblastoma treatment requires significant multidisciplinary input, but early detection through raising awareness remains key to improving outcomes. In the second article of a two-part series, Manoj Parulekar discusses retinoblastoma management, screening and research. This article has been published in two...
