You searched for "IRD"
Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
4 August 2021
| Jane Ashworth, Tsveta Ivanova, Susmito Biswas, Assad Jalil, Georgina Hall, Rebecca Redmond, Graeme CM Black (Prof), William Newman, Neil Parry, Jane CB Gray, Charlotte Skitterall
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Ophthalmology, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...
An update on inherited retinal disorders (part 1) – overview and assessment of inherited retinal disease
1 October 2016
| Michel Michaelides (Prof)
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Retina / Uvea / Vitreous
Part 2 of this topic can be found here Inherited Retinal Disease (IRD) is the leading cause of blindness certification in the working age population (age 16-64 years) in England and Wales and the second most common in childhood [1]....
UK Eye Genetics Group (UK-EGG) 2024
10 June 2024
by Mohammed Aslam, FY 3 Doctor, Calderdale and Huddersfield NHS Foundation Trust, UK. Founded in 2002, the UK EGG provides a hub to share knowledge on inherited eye disease and train the next generation of clinicians and scientists. This year’s...
Inherited retinal disorders now the leading cause of blindness
1 April 2014
| Thomas O'Neill
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Retina / Uvea / Vitreous
The recent paper in BMJ Open, from the UCL Institute of Ophthalmology, ‘A comparison of the causes of blindness certifications in England and Wales in working age adults (16-64 years), 1999-2000 with 2009-2010’ concludes that inherited retinal disorders (IRD) such...
Insights in resistant diabetic macular oedema
5 August 2022
| Sofia Rokerya
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Retina / Uvea / Vitreous
This article gives a bird’s eye review of the different modalities for the treatment of diabetic macular oedema (DME). The debut of anti-VEGFs has brought a paradigm shift in DME management. This treatment has now become a major breakthrough in...
An update on inherited retinal disorders (part 2): Approaches to therapy for IRDs
1 December 2016
| Stacey Strong, Michel Michaelides (Prof)
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Retina / Uvea / Vitreous
Part 1 of this topic can be found here There are currently no proven cures for inherited retinal disease (IRD). However, multiple avenues of research are being investigated to better understand disease mechanisms and trial potential therapies that may slow...
Hereditary profile of retinal detachment
1 August 2016
| Huw Edward Oliphant
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Retina / Uvea / Vitreous
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gene, genetics, idiopathic, non-syndromic, rhegmatogenous retinal detachment, syndromic
This review sought to clarify some of the heritable elements of rhegmatogenous retinal detachment (RRD). The familial element of RRD is well established, with the sibling recurrence risk ratio being 2.1 (Mitry and colleagues), and the parent-offspring recurrence risk ratio...
Does paediatric rhegmatogenous retinal detachment (RRD) obey Lincoff’s rule (LR)?
3 February 2023
| Su Young
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Retina / Uvea / Vitreous
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Lincoff‘s rule, pediatric, retinal break, rhegmatogenous retinal detachment
This was a retrospective study where 98 paediatric patients with RRD were identified through surgery records. Forty case sheets with complete record of ocular examination and surgical findings were analysed. Visible or suspected preoperative retinal break identified using the LR...
Cystoid macular oedema following retinal detachment surgery
5 April 2022
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Cystoid macular edema, rhegmatogenous retinal detachment, vitreoretinal surgery
There are limited studies examining the incidence and risk factors for postoperative cystoid macular oedema (CMO) following rhegmatogenous retinal detachment (RRD) repair. Postoperative CMO is thought to be due to pro-inflammatory state, where numerous cytokines lead to tight junction dysfunction,...
Air tamponade in pars plana vitrectomy for primary rhegmatogenous retinal detachment repair
1 June 2022
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Air tamponade, Multiple retinal tears, Pars plana vitrectomy, Retinal detachment surgery
The authors report a study aimed to establish the use of air as a tamponade agent for primary rhegmatogenous retinal detachment (RRD) treatment, regardless of the position or the number of retinal breaks. Two hundred and thirty-six eyes of 230...
Comprehensive review of inherited retinal diseases
3 June 2024
| Zhihang Cheng
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Retina / Uvea / Vitreous
The authors offer an up-to-date review of inherited retinal diseases (IRDs). In each section the authors discuss the molecular basis of disease, genotype and clinical manifestation. They also discuss the investigation findings and current evidence in the treatment of the...
Visual acuity outcomes in Coat’s disease by classification stage
5 October 2020
| Jonathan Chan
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Retina / Uvea / Vitreous
This is a retrospective study of 160 consecutive patients with Coat’s disease under the Shields classification, with Snellen visual acuity (VA) pre and post treatment. Affected eyes were categorised based on the Shields classification: Stage 1: retinal telangiectasia onlyStage 2a:...