You searched for "eye disease"
Strabismus in thyroid eye disease
1 April 2017
| Richard Harrad
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Paediatric Ophthalmology / Strabismus
Pathogenesis Thyroid eye disease (TED) is an auto-immune condition, in the initial phase there is lymphocytic infiltration and oedema of the extraocular muscles with deposition of glycosaminoglycans and hyaluronic acid and adipogenesis, which can lead to an increase in the...
Thyroid eye disease
Thyroid eye disease (TED) is an autoimmune condition with a spectrum of signs and symptoms, usually associated with Graves’ hyperthyroidism. The diagnosis is based on history and physical examination but there are further investigations that can aid diagnosis if unclear....Recurrent thyroid eye disease
1 April 2016
| James Hsuan
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Neuro-Ophthalmology
This study investigates the incidence of recurrent thyroid eye disease. The authors retrospectively reviewed the records of 415 patients who had been diagnosed with thyroid eye disease between 2006 and 2012. The medical notes were scrutinised for evidence of a...
Vitamin D and thyroid eye disease
This is a retrospective review of vitamin D levels in patients with thyroid eye disease (TED). Vitamin D levels in 89 patients with Grave’s disease and TED were compared against 89 patients with Grave’s disease and no TED. They also...Assessment and management of dry eye disease
1 August 2018
| Sofia Rokerya
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Cataract and Refractive
This paper is an update on the assessment and management of dry eye disease (DED). According to the second International Dry Eye Workshop 2017, “Dry eye is a multifactorial disease of the ocular surface characterised by a loss of homoeostasis...
Incomplete teprotumumab treatment for thyroid eye disease
This is a multi-centre retrospective analysis of clinical outcomes in patients who were on teprotumumab for thyroid eye disease but had the usual regime of eight infusions, three weeks apart, interrupted due to COVID-19. Manufacturing was suspended between Dec 2020...Rituximab as an immunosuppression treatment for thyroid eye disease
1 October 2015
| Claire Howard
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Neuro-Ophthalmology
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Biologic therapy, Graves disease, Graves orbitopathy, ophthalmopathy rituximab, thyroid-associated orbitopathy, thyroid eye disease
Thyroid eye disease is traditionally treated with high dose glucocorticosteroids and surgical orbital decompression, where responses are often inadequate. This medical treatment is centred around symptom control and reduction of thyroid hormone synthesis, not immunosuppression. Rituximab is an anti-CD20 monoclonal...
Thyroid eye disease and obstructive sleep apnoea
1 August 2019
| James Hsuan
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Neuro-Ophthalmology
This is a retrospective study looking for an association between compressive optic neuropathy in thyroid eye disease (TED-CON) and obstructive sleep apnoea (OSA). One hundred and nine patients with thyroid eye disease were asked to complete a validated questionnaire designed...
Association between diabetes mellitus and dry eye disease
1 April 2020
| Patty Mopamboli Mboli
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Retina / Uvea / Vitreous
Diabetes mellitus (DM) is currently one of the most prevalent chronic diseases in the United States. It is estimated that 12.3% of Americans suffer from DM. In this study the authors compare between dry eye and diabetes mellitus among a...
Exploiting nature’s randomised trials of eye disease
1 December 2022
| Skanda Rajasundaram, Dalia Abdulhussein, Christopher Bentley (Prof), Shafi Balal, Minak Bhalla
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Ophthalmology, Genetics
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...
Tear production levels and dry eye disease
1 April 2019
| Kurt Spiteri Cornish
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Cornea / External Eye Disease
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Dry eye disease, Schirmer I test, clinical tests, large population of patients, tear production levels
Dry eye disease (DED) is multifactorial, caused by an alteration in the quality or quantity of tear film’s three layers. Several tests are available for diagnosis. The aim of this study was to determine if the Schirmer test (ST) could...
Visual field changes in thyroid eye disease (TED)
1 April 2018
| Jaya Myneni
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Oculoplastics, Orbit
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Thyroid eye disease, compressive optic neuropathy, visual field
This study is a retrospective non- comparative review of visual field (VF) tests in patients with compressive optic neuropathy from thyroid eye disease (TED-CON). Ninety-six visual fields in 68 patients were included in the study and a two-step analysis of...