You searched for "melanocytes"
Limbal melanocytes and the stem cell niche
1 February 2016
| Graham Wallace
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Retina / Uvea / Vitreous
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Cell interactions, Cornea, Limbal stem cells, Melanocytes, Stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Melanocytoma of the optic disc
1 June 2015
| Lucia Derriman, Sumith Perera
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AMD, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Cataract and Refractive, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Melanocytoma is a heavily pigmented lesion, composed of melanocytes and is a variant of melanocytic naevus. It classically occurs at the optic disc and is usually benign, static and asymptomatic. However, it can occasionally grow and invade the retina or...
A mouse model for uveal melanoma
1 December 2014
| Graham Wallace
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Ocular Pathology and Oncology
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Grm1, melanoma, metabotropic glutamate receptor, mouse model, uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
Diffuse lamellar keratitis
5 August 2020
| Inderpaul S Sian
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Cataract and Refractive
This study group reviewed cytokine- and chemokine-mediated mechanisms of diffuse lamellar keratitis (DLK) after lamellar corneal surgical procedures. DLK can occur early or late (months to decades) after all lamellar corneal surgeries, including laser in situ keratomileusis, small incision lenticule...
Quiz Oct/Nov 2024
History An 83-year-old female was previously treated by surgical excision and plaque brachytherapy for her left conjunctival lesion. She presented to her ophthalmologist with a recurrence some years later and underwent a lid sparing orbital exenteration, which was sent to...Stromal cell alignment in damaged cornea
1 August 2017
| Graham Wallace
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Cornea / External Eye Disease
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Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
Late stromal rejection in DALK
1 December 2016
| Magdalena Popiela
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Cornea / External Eye Disease
This case series reported on late stromal rejections in eyes after uncomplicated deep anterior lamellar keratoplasties (DALKs). Four eyes of three patients experienced episodes of isolated stromal rejection 33 to 46 months after surgically uncomplicated DALKs and a minimum of...
Suspected vitreous seeding of uveal melanoma
This is a retrospective non-randomised study of 23 patients with consecutive uveal melanoma who underwent diagnostic vitrectomy between the period of January 2000 and November 2013. The reason for vitrectomy was suspected dissemination of tumour cells inside the eye. The...Presentation of conjunctival intraepithelial neoplasia
7 April 2021
| Annes Ahmeidat
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Cornea / External Eye Disease
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Conjunctival intraepithelial neoplasia, Conjunctival melanoma, Pigmented conjunctival lesion
Ocular surface squamous neoplasia is the umbrella term for malignancies of the conjunctiva and within the spectrum lies conjunctival intraepithelial neoplasia (CIN) – a non-invasive malignancy. CIN has been implicated with ageing, smoking and ultraviolet light exposure. The typical manifestation...
“Beware of the pigment”
Using some captivating artwork, Iheukwumere Duru describes key features of pigment dispersion syndrome. Pigmentary dispersion syndrome (PDS) leads to pigmentary glaucoma (PG) in approximately 35-50% of patients with the condition [1]. PG is the leading cause of non-traumatic blindness in...Corneal lenticule allotransplant
1 April 2017
| Magdalena Popiela
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Cornea / External Eye Disease
This animal study looked at corneal lenticule allograft transplantation in rabbits. Seven rabbits underwent small incision lenticule extraction (SMILE) procedures, where their stromal lenticules were extracted and transplanted fresh into pre-prepared corneal stromal pockets of seven recipient eyes. Animals were...
Confocal microscopy and corneal graft rejection
1 February 2016
| Magdalena Popiela
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Cornea / External Eye Disease
Forty-five patients following penetrating keratoplasty (PK) were examined with the HRT III Rostock Cornea Module confocal microscope at various points after their surgery for two years. Activated keratocytes (AKs) were counted manually and their mean number evaluated. A pattern was...