You searched for "melanoma"
Uveal melanoma
3 August 2023
| Mertcan Sevgi, Timothy Beckman, Paul Cauchi, Julie Connolly, Vikas Chadha
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EYE - Pathology, EYE - Oncology, EYE - Imaging
Uveal melanoma is the most common primary intraocular tumour. However, they are still rare, with an incidence of 2-8 per million [1]. The presence of a choroidal naevus is a risk factor for uveal melanoma [1]. Patients with choroidal lesions...
A mouse model for uveal melanoma
1 December 2014
| Graham Wallace
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Ocular Pathology and Oncology
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Grm1, melanoma, metabotropic glutamate receptor, mouse model, uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
Germline testing for uveal melanoma
4 December 2023
| Ian Reekie
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Ocular Pathology and Oncology
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BAP1, Uveal melanoma, genetic counselling, hereditary cancer, mainstreaming, service delivery
The authors present a study of 114 consecutive patients presenting with uveal melanoma. Between 1 December 2019 and 1 November 2021 all patients over 18-years-old presenting to their centre with uveal melanoma were offered germline testing for variants in BAP1,...
Prognostication for uveal melanoma
1 October 2017
| Yamini Krishna
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Paediatric Ophthalmology / Strabismus
The authors highlight the importance of using all available data in the prognostication of uveal melanoma (UM). Over recent years a number of molecular tests have emerged to allow clinicians to predict metastatic potential of UM. However, concordance between techniques...
Suspected vitreous seeding of uveal melanoma
This is a retrospective non-randomised study of 23 patients with consecutive uveal melanoma who underwent diagnostic vitrectomy between the period of January 2000 and November 2013. The reason for vitrectomy was suspected dissemination of tumour cells inside the eye. The...Choroidal melanoma – breaking bad news
1 June 2019
| Kirupakaran Silas Arun, Assid Jaleel
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Ocular Pathology and Oncology
Case report A 55-year-old Caucasian female presented to her general practitioner with a three-month history of headaches and worsening blurred vision in the left eye. On further close questioning, she reported no eye pain, intermittent floaters and flashes of light...
Ciliary body granuloma masquerading as a melanoma
3 February 2023
| Boon Lin Teh, Paul Cauchi, Lucia Kuffová
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Ophthalmology
Introduction Sarcoidosis is a multisystem granulomatous inflammatory condition which predominantly affects the pulmonary system and intrathoracic lymph nodes, followed by ocular involvement [1]. We present an interesting patient who developed acute anterior uveitis and subsequent ciliary body granuloma clinically mimicking...
Tumour deposits following choroidal melanoma treatment
7 April 2021
| Annes Ahmeidat
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Retina / Uvea / Vitreous
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Choroidal melanoma, Metastasis, Recurrence, Retinal melanoma, Retinoinvasive melanoma, Uveal melanoma
The authors present the unique case of retinoinvasive melanoma following treatment of choroidal melanoma with brachytherapy. Uveal melanoma, the commonest intraocular malignancy in adults, presents as a pigmented mass in the choroid, ciliary body, or iris. A 79-year-old Caucasian male...
Conjunctival melanoma involving the lacrimal drainage system
A total of 52 patients were diagnosed with conjunctival melanoma over a period of 17 years, 17 of whom required orbital exenteration. Five of these were found to have melanoma involving the lacrimal drainage apparatus (LDA). One was evident clinically...Practice patterns of uveal melanoma management with Iodine-125 brachytherapy
5 August 2020
| Annes Ahmeidat
|
Ocular Pathology and Oncology
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Brachytherapy, Treatment practices, Uveal melanoma
With the 2006 Collaborative Ocular Melanoma Study Group (COMS) study demonstrating no difference in survival outcomes for participants randomised to either iodine-125 brachytherapy or enucleation, the majority of primary uveal melanomas in the United States are now treated with brachytherapy....
Cutaneous malignant melanoma metastasis to pseudophakic lens
4 February 2021
| Annes Ahmeidat
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Ocular Pathology and Oncology
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Cutaneous melanoma, Diagnostic vitrectomy, Granulomatous inflammation, Malignant melanoma, Metastasis, Posterior capsule, Uveitis
Metastases to the eye and orbit are rare and intraocular cutaneous malignant melanoma metastasis (ICMM) is exceedingly rare, representing around 5%. There have only been three previous cases of ICMM to the lens in the literature, all of which presented...
Quality of life concerns after uveal melanoma diagnosis
5 August 2020
| Annes Ahmeidat
|
Ocular Pathology and Oncology
The authors sought to investigate factors associated with Quality Of Life (QOL) after initial diagnosis of uveal melanoma (UM) using prospectively collected data between September 2011-May 2016. They included 201 participants referred for radiotherapy after UM diagnosis by an ophthalmic...