You searched for "sclerosis"
Ocular manifestations of multiple sclerosis: an overview
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), in which there is dissemination of lesions in time (two or more clinical events) and space (multiple lesions seen on brain and spinal imaging). The pathophysiology...Mechanism of colour vision involvement in multiple sclerosis
5 August 2020
| Claire Howard
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Neuro-Ophthalmology
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Multiple sclerosis, red/green, blue/yellow, colour vision, psychophysics
There is evidence to show that the optic nerve and retina are affected in multiple sclerosis (MS) even without any clinical evidence or history of optic neuritis (ON). MS without optic neuritis causes colour-vision deficit, however, the evidence for selective...
Sub-clinical detection methods in multiple sclerosis
3 April 2023
| Claire Howard
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Neuro-Ophthalmology
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Subclinical multiple sclerosis, axonal degeneration, frequency-doubling perimetry, optic neuritis, optical coherence tomography, standard automated perimetry
Visually symptomatic multiple sclerosis (MS) provides only part of the required information to assist in understanding the disease. Recently, researchers have concentrated their efforts on diagnosing MS cases in the subclinical period. The aim of this paper was to assess...
Predicting outcome for visual acuity in optic neuritis associated with multiple sclerosis
3 October 2024
| Lauren R Hepworth
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Neuro-Ophthalmology
The authors present a retrospective cohort study to evaluate key predictors of long-term high-contrast visual acuity following optic neuritis associated with multiple sclerosis. All patients coded as optic neuropathy and assessed by a neuro-ophthalmologist over a 10-year period were screened...
Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)
1 April 2018
| Claire Howard
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Neuro-Ophthalmology
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Amyotrophic lateral sclerosis, colour vision, desaturated L’Anthony D-15, retinal disease
The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...
Correlation between structural and functional status of optic nerve and retina in multiple sclerosis
1 August 2014
| Claire Howard
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Neuro-Ophthalmology
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Multiple sclerosis, optical coherence tomography, perimetry, retinal nerve fibre layer thickness, visual evoked potentials
Multiple sclerosis (MS) involves autoimmune inflammatory demyelination and axonal degeneration in the central nervous system. Investigation of the retina and optic nerve head (ONH) is an ideal way to visualise this demyelination. This study investigates the functional and structural properties...
New prognostic model for multiple sclerosis after optic neuritis presentation
2 August 2022
| Lauren R Hepworth
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Neuro-Ophthalmology
The authors present a post-hoc analysis using the publicly available data set from the Optic Neuritis Treatment Trial. The Cox proportional hazards regression models were used to assess for associations between clinical and radiological variables and the development of clinical...
Likelihood of developing multiple sclerosis after optic neuritis diagnosis
3 April 2024
| Jonathan Chan
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Neuro-Ophthalmology
Optic neuritis (ON) is a relatively common cause of acute optic neuropathy in young patients which often presents as the first sign of multiple sclerosis (MS). There is a lack of evidence around the factors that are associated with the...
Amyotrophic lateral sclerosis (ALS): what happens to eye movements?
3 February 2023
| Claire Howard
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Neuro-Ophthalmology
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Eye movement, amyotrophic lateral sclerosis, anti-saccades; biomarker, pursuit, saccades
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper motor neurons of the corticospinal tract and lower motor neurons in brainstem nuclei and the anterior horn of the spinal cord. Limited literature is available on abnormal ocular movements in...
Case series of posterior scleritis
1 October 2014
| Saruban Pasu
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Ocular Pathology and Oncology
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Scleritis, Ocular inflammatory disease, Inflammation, Sclera
This report aimed to facilitate the correct diagnosis of posterior scleritis, a condition which is usually overlooked or misdiagnosed. Electronic health records of 31 patients with posterior scleritis were analysed and compared to a group with isolated anterior scleritis of...
Dacryocystosclerotherapy as an alternative to dacryocystectomy
2 December 2019
| Rina Bhatt
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Oculoplastics, Orbit
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Lacrimal, bleomycin, dacryocystectomy, dacryocystosclerotherapy, sclerotherapy
In this article, the authors evaluate the role of sclerosing agents in dacryocystosclerotherapy (DCST) and aim to see whether it is an alternative to dacryocystectomy (DCT) in a specific group of patients. Thirteen lacrimal drainage systems of 10 patients with...
Development of testing protocols for high and low contrast visual acuity
1 April 2018
| Claire Howard
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Neuro-Ophthalmology
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Amyotrophic lateral sclerosis, LCD tablet, high-contrast visual acuity, low-contrast visual acuity, pinhole
Dysfunction of the afferent visual system, characterised by impairments in high-contrast visual acuity (HCVA) and low-contrast visual acuity (LCVA) have been demonstrated in some neurological conditions such as multiple sclerosis and Parkinson’s disease. HCVA and LCVA are also potential quantitative...